Abstract
Garlic-induced Proteomic Change, Anti-biofilm and Antifungal Susceptibility of Candida albicans
Highlights
Candida species are natural commensals of the human microbial flora, and it is considered opportunistic pathogen (Hallen-Adams and Suhr 2017)
This study aimed to explore the antifungal and antibiofilm activity of garlic extract on Candida albicans, and the associated polymorphism of protein bands
Studies on Candida infections in some countries showed that Candida albicans (C. albicans) was the most commonly isolated species with prevalence ranging from 22.3% to 60%
Summary
Candida species are natural commensals of the human microbial flora, and it is considered opportunistic pathogen (Hallen-Adams and Suhr 2017). Studies on Candida infections in some countries showed that Candida albicans (C. albicans) was the most commonly isolated species with prevalence ranging from 22.3% to 60%. The misuse of antifungal agents has led to the growing antifungal resistance of C. albicans and the rise of non- albicans Candida species (Kmeid, Jabbour et al, 2020). Fluconazole resistance in Candida spp. has been reported increasingly in C. albicans, and requires the search for new therapeutic options. Biofilms are a barrier to treatment as they are often resistant to antifungal drugs. New antifungal agents should be tested for their effects on planktonic as well as biofilm-inhibiting and eradicating abilities (Berkow and Lockhart 2017).
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