Gardasil-9 Vaccine as a Possible Treatment Option for Human Papillomavirus Conjunctival Papilloma

Abstract

The authors describe the clinical progression of a 9-year-old boy with unilateral, severe conjunctival papillomatosis (CP; Fig A-B). Histopathological diagnosis showed squamous cell papilloma (Fig C) and evidence of human papillomavirus-6 (HPV-6) infection with polymerase chain reaction, and histopathological immunohistochemistry demonstrated HPV P16 (cyclin-dependent kinase inhibitor p16) focal patchy reactivity (Fig D). Over 24 months, he had recurrent CP despite management with surgical excision, cryotherapy, and subconjunctival interferon therapies.