Abstract
The aim of this study was to explore the effects of Garcinia mangostana (mangosteen) and Curcuma longa independently and synergistically in modulating oxidative stress, dyslipidemia, and hyperglycemia commonly observed in high-fat diet-induced obesity in rodent models. Male albino Wistar rats were divided into eight experimental groups, fed on a normal diet or high-fat diet (HFD), then given mangosteen extract (400 mg /kg /day) and/or curcumin (80 mg/kg /day) for 6 weeks. Oxidative stress markers, glucose, and lipid fractions were measured in the sera. Mangosteen pericarp extract (MPE) induced a remarkable decrease in BMI (from 0.86 to 0.81 gm/cm2), while curcuma either alone or in combination was more effective, as treated rats recorded BMIs of 0.78 and 0.79 gm/cm2, respectively. Regarding the antioxidant effects, MPE induced a significant increase of GSH in obese rats (123.86 ± 15.53 μg/ml vs 288.72 ± 121.37 μg/ml). As anti-atherogenic agents MPE demonstrate significant effect recorded higher level of HDL-C in treated animals, but ineefective as anti-dyslipidemic agent. Curcumin was more effective in reducing LDL-C levels in obese rats. Both extracts effectively reduced blood glucose. The present study demonstrated that MPE and curcumin were independently and synergistically effective in treating obesity-induced atherogenesis.
Highlights
The aim of this study was to explore the effects of Garcinia mangostana and Curcuma longa independently and synergistically in modulating oxidative stress, dyslipidemia, and hyperglycemia commonly observed in high-fat diet-induced obesity in rodent models
Weight gain, and body mass index (BMI) in normal and high-fat diet (HFD)-induced obese rats in response to mangosteen extract and curcumin are shown in Table 1 and Fig. 1
While the BMI in obese controls (Group 5) reached 0.86 ± 0.09 gm/cm[2], the normal diet controls (Group 1) recorded a significantly lower BMI of 0.55 ± 0.04 gm/cm[2] (p 0.001). Both mangosteen extract and curcumin ameliorated the increase in BMI as measure of obesity; while Mangosteen pericarp extract (MPE) induced a remarkable decrease in BMI, curcuma either alone or in combination was more effective, as BMIs were reduced to 0.78 and 0.79 gm/cm[2], respectively
Summary
The aim of this study was to explore the effects of Garcinia mangostana (mangosteen) and Curcuma longa independently and synergistically in modulating oxidative stress, dyslipidemia, and hyperglycemia commonly observed in high-fat diet-induced obesity in rodent models. Accumulating evidence shows that the quality of diet has demonstrated a negative shift toward consumption of high-energy foods, while intake of nutrient-rich foods such as fruits and vegetables has d ecreased[6,7]. Such low-quality diets have been linked to a higher risk of o besity[8] dietary modification is frequently recommended as the main approach in prevention and treatment of obesity[9,10].
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