Gap junctions facilitate propagation of synchronous firing in the cortical neural population: A numerical simulation study

Abstract

This study investigates the effect of gap junctions on firing propagation in a feedforward neural network by a numerical simulation with biologically plausible parameters. Gap junctions are electrical couplings between two cells connected by a binding protein, connexin. Recent electrophysiological studies have reported that a large number of inhibitory neurons in the mammalian cortex are mutually connected by gap junctions, and synchronization of gap junctions, spread over several hundred microns, suggests that these have a strong effect on the dynamics of the cortical network. However, the effect of gap junctions on firing propagation in cortical circuits has not been examined systematically. In this study, we perform numerical simulations using biologically plausible parameters to clarify this effect on population firing in a feedforward neural network. The results suggest that gap junctions switch the temporally uniform firing in a layer to temporally clustered firing in subsequent layers, resulting in an enhancement in the propagation of population firing in the feedforward network. Because gap junctions are often modulated in physiological conditions, we speculate that gap junctions could be related to a gating function of population firing in the brain.