Abstract
ABSTRACT Diabetic rats were daily fed with a high-cholesterol diet containing 1% or 3% freeze-dried whole submerged G. lucidum culture or its mycelia for 5 weeks. Body weight, adipose tissue weight and plasma triglyceride levels were reduced, while high-density lipoprotein-cholesterol levels were elevated in rats fed with G. lucidum powder supplement diets. Notably, G. lucidum supplements downregulated the activities of hepatic acetyl-CoA carboxylase, fatty acid synthase and lipoprotein lipase, but upregulated the activity of hormone-sensitive lipase in the perirenal adipose tissues. Moreover, G. lucidum supplements increased the faecal triglyceride excretion. Therefore, daily supplementation of submerged G. lucidum culture, especially mycelia, can ameliorate dyslipidemia and reduce visceral fat accumulation in diabetic rats fed with a high-fat diet, which is closely related to the modulation of lipid synthesis, metabolism, and excretion.
Highlights
Type 2 diabetes is a chronic metabolic disease with hyperglycaemia and insulin resistance
Daily supplementation of submerged G. lucidum culture, especially mycelia, can ameliorate dyslipidemia and reduce visceral fat accumulation in diabetic rats fed with a high-fat diet, which is closely related to the modulation of lipid synthesis, metabolism, and excretion
Supplementation with a submerged culture of G. lucidum ameliorated hyperlipidaemia and visceral fat accumulation in diabetic rats fed with a high-cholesterol diet
Summary
Type 2 diabetes is a chronic metabolic disease with hyperglycaemia and insulin resistance. Visceral fat is thought to be the culprit in the development of insulin resistance, which plays an important role in the pathogenesis of dyslipidemia in type 2 diabetes (Patel and Abate 2013). Type 2 diabetes is associated with abnormal plasma lipids and lipoproteins, including decreased high-density lipoprotein cholesterol (HDLC), predominant low-density lipoprotein cholesterol (LDL-C), and elevated triglyceride (TG) levels. These dyslipidemia characteristics increase the risk of cardiovascular disease (Nelson 2013). Exercise, and weight management may improve diabetic dyslipidemia and body fat accumulation, pharmacological treatment is still needed (Krauss 2004)
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