Abstract
Ganoderic acid (GA), produced by submerged culture of Ganoderma lucidum, at 500 microg/ml, caused nearly a 70% inhibition of the growth of human hepatoma cell line BEL7402 but not of a normal human liver cell line L02. Flow cytometry analyses showed that GA blocked the BEL7402 cell cycle at the transition from G(1 )to S phase.
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