Abstract
AbstractGangliosides from bovine optic nerve were analyzed. The optic nerve contained 129, 98, 97, 80, 31 and 12 μg of GM1, GD1a, GD1b, GT1b, GD3 and GQ1 gangliosides, respectively, per g of tissue wet wt. These 6 gangliosides altogether contributed 97% of the total sialic acid. GM3 and GM2 gangliosides contributed the remaining 3% of total sialic acid. Stearoyl (18∶0) was the predominant acyl group (61–76%) in all gangliosides. There was a marked variation in acyl group composition between GT1 and most of the other major gangliosides except GD3. In comparison to the other gangliosides, GT1 contained a lower proportion of the stearoyl group and a higher proportion of the oleoyl, nervonoyl and the long chain acyl groups. Both GT1 and GD3 gangliosides contained proportionately higher levels of long chain acyl groups (20∶0→24∶0) than did other gangliosides. GD3 gangliosides showed 2 bands on thin layer chromatography, and the upper band was more distinct than the lower band.
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