Ganglioside for hand, foot and mouth disease complicated with central nervous system damage

Abstract

Objective To explore the efficacy of Ganglioside for hand, foot and mouth disease ( HFMD )complicated with central nervous system damage in pediatric patients.Methods 140 pediatric patients with HFMD complicated with central nervous system damage who were hospitalized into our hospital from Feb.2009 to Feb.2011 were randomly divided into treatment group and control group,70 for each group.All patients in both groups were treated with anti-virus drug and anti-infectious drug and received symptomatic treatment.Besides these,patents in treatment group were intravenously cured with 20 mg ganglioside for 10 days,while patients in control group were intravenously treated with citicoline,0.125-0.25 g/d.The electroencephalogram ( EEG ) and neuron-specific enolase ( NSE ),the duration of main symptoms and signs,time to recover,and hospital stay of the two groups were compared and analyzed.Results 65( 92.8％ ) patients in treatment group recovered in electroencephalogram( EEG )and neuron-specific enolase( NSE ).the duration of the main symptoms and signs,time to recover,and hospital stay were significantly shorter in treatment group than in control group ( P ＜ 0.05 ).Conclusions Ganglioside for hand,foot and mouth disease ( HFMD ) complicated with central nervous system damage is efficacious safe,and reliable and can reduce sequelae incindence. Key words: Hand, foot and mouth disease; Central nervous system; Ganglioside; Citicoline