Abstract
Abstract Introduction: The application of opioid drugs close to sympathetic ganglia (ganglionic local opioid analgesia, GLOA) has been reported to provide good pain relief in certain chronic pain syndromes. In the present prospective, randomized, double-blind, placebo-controlled, crossover study, the analgesic efficacy of GLOA versus saline injections was compared in patients suffering from refractory trigeminal neuralgia. Methods: A total of 19 patients were treated once a day for two 5-day periods with a series of either GLOA or saline injections, respectively, using a cross-over design. All applications were exclusively performed at the ganglion cervicale superius (GCS) of the affected side. The verum-GLOA consisted of 0.045 mg buprenorphine in 1.5 ml 0.9% NaCl, the placebo-GLOA of 1.5 ml 0.9% NaCl only. Pain reduction was measured with a visual analogue scale (VAS) before and after each injection. Data were analysed using analysis of variance. Results: Surprisingly, an almost identical, significant pa...
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