Abstract
STRUCTURE: Ganaxolone is a 3β-methylated synthetic analog of the natural neurosteroid allopregnanolone, a metabolite of progesterone. It is also called 3α-hydroxy-3β-methyl-5α-pregnan-20-one and has a molecular formula C22H36O2, with a molecular weight of 332.5 g/mol. The 3β-methyl substitution prevents rapid metabolism and thus increases its stability (terminal half-life: 34 h). Ganaxolone is a white crystalline powder that is insoluble in water but soluble in organic solvents.
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