Gamma Oscillations and Excitation/Inhibition Imbalance: Parallel Effects of NMDA Receptor Antagonism and the Psychosis Risk Syndrome

Erica Duncan,Daniel H Mathalon ,Margaret A Niznikiewicz ,Diana O Perkins ,Scott W Woods ,Brian Roach ,Elaine F Walker ,Kristin S Cadenhead ,Barbara A Cornblatt ,Gregory A Light ,Judith M Ford ,Ayşenil Belger ,Jean Addington,Ricardo Carrión ,Larry J Seidman ,Tyrone D Cannon ,Thomas H Mcglashan ,Peter Bachman,Carrie E Bearden ,Ming T Tsuang ,Jason Johannesen

doi:10.1016/j.biopsych.2020.02.270

Gamma Oscillations and Excitation/Inhibition Imbalance: Parallel Effects of NMDA Receptor Antagonism and the Psychosis Risk Syndrome

Erica Duncan, Daniel H Mathalon + Show 19 more

https://doi.org/10.1016/j.biopsych.2020.02.270

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Journal: Biological Psychiatry	Publication Date: May 1, 2020
Citations: 1

Affiliation: Emory University, Veterans Health Administration, University of California, San Francisco, Harvard University, Yale University, Northern California Institute for Research and Education, University of California, San Diego, Zucker Hillside Hospital, San Francisco VA Health Care System, University of Calgary, University of Pittsburgh, University of California, Los Angeles

#Baseline Gamma Power #Auditory Steady State Response Power + Show 8 more

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Abstract

NMDA receptor (NMDAR) hypofunction is a putative pathophysiological mechanism theorized to contribute to deficient stimulus-evoked gamma oscillations and excessive baseline gamma power (reflecting excitation/inhibition (E/I) imbalance) in schizophrenia. We examined the effect of the NMDAR antagonist, ketamine, on the 40Hz auditory steady state response (ASSR) and pre-stimulus baseline gamma power. Further, we examined 40Hz ASSR and baseline gamma power in psychosis risk syndrome (PRS) youth.

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