Abstract
<p id="C2">Multi-sensory integration (MSI) refers to a comprehensive process of selecting, connecting, unifying, and interpreting different sensory information. It involves coordination among various brain regions to achieve temporal binding of multiple sensory information and global predictive encoding. On the other hand, gamma oscillation plays vital roles in MSI, due to its versatile functions in reflecting excitation/inhibition balance of interneuron, implementing temporal binding of multi-sensory information, and participating in global predictive encoding via a cross-frequency coupling mechanism. Multisensory integration deficits are typical symptoms of patients with autism spectrum disorders (ASD). Research shows that patients with ASD usually exhibit abnormal gamma oscillations caused by structural and functional abnormalities in GABA interneurons. In turn, these abnormal gamma oscillations disrupt temporal binding and predictive encoding, and eventually lead to MSI deficits in ASD. As a result, future research could use gamma rhythm neural oscillation as a biofeedback indicator, in combination with non-invasive and reversible intervention technologies, to develop scientific and systematic clinical intervention treatments.
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