Abstract
The effect of Rhodiola sachalinensis Boriss extract irradiated with 50 kGy gamma rays (HKC) on benign prostatic hyperplasia (BPH) was investigated. Seven-week-old male SD rats received a subcutaneous injection of 20 mg/kg of testosterone propionate (TP) to induce BPH. Then, the testosterone only group received testosterone, the testosterone + finasteride group received testosterone and finasteride (5 mg/kg), the testosterone + HKC group received testosterone and HKC extract (500 mg/kg). Prostate weight and the dihydrotestosterone (DHT) levels in serum or prostate tissue were determined. The mRNA expressions of 5-alpha reductase (AR) in prostate tissue were also measured. Compared to the control group, prostate weight was significantly improved in the TP group and decreased in the HKC and finasteride-treated groups. Furthermore, the mRNA expression of 5-AR in the prostate was significantly reduced in the HKC and finasteride-treated groups. Similarly, the expression levels of α-smooth muscle actin (α-SMA) and cytokeratin, which are associated with prostatic enlargement in the HKC and finasteride groups, were much lower than in the TP group. HKC treatment showed similar efficacy to finasteride treatment on rats with testosterone-induced BPH. HKC may be explored as a potential new drug for BPH treatment.
Highlights
Benign prostatic hyperplasia (BPH) is characterized by the nonmalignant overgrowth of the prostatic tissue and stromal cells within the transitional zone and periurethral area [1,2]
HKC was safe as there were no significant differences in alanine aminotransferase (ALT) and aspartate transaminase (AST) activities among all of the groups
Boriss extract extract irradiated irradiated with 50 kGy gamma gamma rays) on on the the activity of (AST)/alanine aminotransferase blood urea activity of aspartate aspartate transaminase blood urea nitrogen
Summary
Benign prostatic hyperplasia (BPH) is characterized by the nonmalignant overgrowth of the prostatic tissue and stromal cells within the transitional zone and periurethral area [1,2]. Testosterone levels decreased with age could benefit this pathology [3], the major factor is 5-alpha reductase (5-AR), which improves the dihydrotestosterone (DHT) level [4]. BPH patients need to be treated via surgery or medication [5,6]. The tomato and black raspberry extracts help prevent and treat BPH by regulating the expression of DHT and 5-AR [9,10]. Even if a material is found to improve prostate enlargement from natural products, it takes a long time to clarify the mechanism [11,12]. Considering that prostate hyperplasia is a long-standing disease according to aging, it is best to find a material that can prevent and treat enlargement of the prostate by effectively taking it safely for a long period
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