Abstract
The effect of gamma-hydroxybutyric acid (GHB) on the excitatory postsynaptic potential (EPSP) evoked in thalamocortical neurones of the rat dorsal lateral geniculate nucleus and ventrobasal thalamus was investigated in vitro. GHB (0.1–5 mM) dose-dependently and reversibly decreased (36–78%) the amplitude of the sensory EPSP. This effect of GHB was blocked by the GABA B receptor antagonist CGP 35348 (1 mM). NCS 382 (1–3 mM), a putative GHB receptor antagonist, did not antagonise but weakly potentiated both the GHB- and baclofen-mediated decrease of the EPSP amplitude.
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