GAMMA-GLUTAMYLTRANSPEPTIDASE IN POLYCYSTIC OVARY SYNDROME

Abstract

Objective: Gamma-glutamyl transpeptidase (GGT) is implicated in oxidative stress previously reported in polycystic ovary syndrome (PCOS). Objective: to investigate gamma-glutamyltranspeptidase (GGT) activity in PCOS. Design and method: We have conducted a case control study. PCOS diagnosis was made based on Rotterdam criteria. Age and Body Mass index (BMI) paired controls were recruted. Biochemical parameters were made by automated methods (Cobas-Roche). Results: The study material consisted of 45 PCOS women and 40 controls. Overweight Obese women with PCOS had significant increased blood pressure and GGT activity. In all the study group, significant correlations were noted between GGT vs menstrual cycle length, GGT vs blood bressure, GGT vs fasting glucose, GGT vs triglycerides, and GGT vs high density lipoprotein cholesterol (HDLc). Moreover, in PCOS significant correlations were observed between GGT and body mass index. Conclusions: These findings suggest that clinical severity of PCOS would be associated to metabolic dysfunctions. The relevance of GGT to BMI and blood pressure in PCOS could be related to various hepatic, lipids, carbohydrates and oxydative alterations in this complex syndrome. Monitoring GGT levels in such patients coud help in disease supervision.