Abstract
It was shown that the level of gamma-carboxyglutamic acid-containing protein is increased in perfused rat kidney after long-term administration (60 and 350 days) of a high-fat diet. No difference was found between the effect of vegetable fat and animal fat. Concomitantly it was shown that the relative molecular weight, N-terminal sequence over four residues, the profile of chymotryptic peptides and the sequence around the two (of the three in total) gamma-carboxyglutamic acid residues (over the span of seven residues) are identical with those found previously in osteocalcin and the gamma-carboxyglutamic acid-containing protein isolated from at least partially calcified connective tissue.
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Schedule a callMore From: Hoppe-Seyler's Zeitschrift fur physiologische Chemie
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