Abstract
Abstract: An average human ejaculate contains over one hundred million sperm, but only a few succeed in accomplishing the journey to an egg by migration through the female reproductive tract. Among these few sperm, only one participates in fertilizing an egg. Surely there must be an ingenious molecular mechanism to ensure that the very best sperm succeed in fertilization. Recent gene manipulation approaches in mice have revealed that many factors previously described as important for fertilization are largely dispensable; however, novel factors are also emerging. For example, sperm from six different gene-disrupted mouse lines (Calmegin, Adam1a, Adam2, Adam3, Ace and Pgap1) are all known to have defective zona binding ability and at the same time lose oviduct migrating ability. Concerning gamete fusion, we found essential factors, IZUMO1 on sperm and CD9 on the egg, in genedisruption experiments. More recently, the structure, localization, and interacting proteins of IZUMO1 are gradually being elucidated....
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
