Abstract
Galvanic Vestibular Stimulation (GVS) has been reported to have beneficial behavioural effects in Parkinson’s Disease (PD), including improving manual tracking performance, improving gait and balance, enhancing interhemispheric connectivity and overall connectivity to the pedunculopontine nucleus (PPN). In this study, we tested the effects of different GVS stimuli on fMRI brain subnetwork interactions in both health control (HC) and PD groups. Twenty-six PD subjects (on medication) and 15 age- and sex- matched controls were recruited in our study and their fMRI data were collected with sham stimulation (i.e., resting state), noisy GVS, 1 Hz sinusoidal GVS, and 70-200Hz multisine GVS conditions. In the subjects’ native space, hippocampal, temporal/insular, basal ganglia, vision/cerebellar, frontal, sensorimotor and default-mode subnetworks were extracted. Subnetwork interaction coefficients were estimated by non-negative canonical correlation analysis (nCCA).
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