Abstract
Galvanic Vestibular Stimulation (GVS) has been reported to have beneficial behavioural effects in Parkinson’s Disease (PD), including improving manual tracking performance, improving gait and balance, enhancing interhemispheric connectivity and overall connectivity to the pedunculopontine nucleus (PPN). In this study, we tested the effects of different GVS stimuli on fMRI brain subnetwork interactions in both health control (HC) and PD groups. Twenty-six PD subjects (on medication) and 15 age- and sex- matched controls were recruited in our study and their fMRI data were collected with sham stimulation (i.e., resting state), noisy GVS, 1 Hz sinusoidal GVS, and 70-200Hz multisine GVS conditions. In the subjects’ native space, hippocampal, temporal/insular, basal ganglia, vision/cerebellar, frontal, sensorimotor and default-mode subnetworks were extracted. Subnetwork interaction coefficients were estimated by non-negative canonical correlation analysis (nCCA).
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
