Gallic acid prevents memory deficits and oxidative stress induced by intracerebroventricular injection of streptozotocin in rats

Abstract

In the present study, we evaluated the effects of gallic acid (GA; 30mg/kg, orally, once daily for 26days starting from day 5 prior to streptozotocin injection) on cognitive impairment and cerebral oxidative stress induced by intracerebroventricular-streptozotocin (ICV-STZ; bilaterally, two doses of 3mg/kg) injection as an animal model of sporadic Alzheimers type (SDAT) in rats. The results showed that ICV-STZ-injection reduced the passive avoidance and spatial memory performance associated with decreased non-enzymatic [total thiol concentration, −58.5%, −50.7%] and enzymatic [superoxide dismutase (SOD, −30.2%, −32.9%), catalase (CAT, −43.5%, −50.7%), glutathione peroxidase (GPx, −57.1%, −61.7%)] activities and increased the level of thio-barbituric acid reactive species (TBARS, +103.5%, +82.5%) in the hippocampus and cerebral cortex, respectively. In contrast, chronic administration of GA significantly prevented cognitive deficits and biochemical alterations in the ICV-STZ rats. These findings highlight the beneficial role of GA in the ICV-STZ rats via enhancement of cerebral antioxidant defense system. Thus, it may have a therapeutic value for the treatment of SDAT.