Abstract
To evaluate the prognostic factors of gallbladder carcinoma. Presentation, operative data, complications, and survival outcome were examined for 132 gallbladder carcinoma patients who underwent gallbladder surgery in our unit during 2002-2007, and follow-up results were obtained from every patient for univariate and multivariate survival analysis. The univariate analysis showed that gallbladder lesion history, tumor cell differentiation, Nevin staging, preoperative lymph node metastasis and the surgical approach significantly correlated with the prognosis of the patients (p <0.05). The results of the multivariate analysis (Cox regression) showed that gallbladder lesion history, Nevin staging and the surgical approach were independent predicators with relative risks of 6.9, 4.4, 2.8, respectively (p=0.002, 0.003, 0.008). Gallbladder lesion history, Nevin staging and the surgical approach are independent prognostic factors for gallbladder carcinoma, a rapidly fatal disease. Therefore, early diagnosis, anti-infective therapy and radical surgery are greatly needed to improve the prognosis of gallbladder carcinoma.
Highlights
The gallbladder carcinoma is a relatively rare disease, despite being the most leading morbidity in tumors of the biliary tract and the fifth most frequent of the gastrointestinal tract, with non-specific clinical presentation and poor prognosis (Fong et al, 2000)
The univariate analysis showed that gallbladder lesion history, tumor cell differentiation, Nevin staging, preoperative lymph node metastasis and the surgical approach significantly correlated with the prognosis of the patients (p
Early diagnosis, anti-infective therapy and radical surgery are greatly needed to improve the prognosis of gallbladder carcinoma
Summary
The gallbladder carcinoma is a relatively rare disease, despite being the most leading morbidity in tumors of the biliary tract and the fifth most frequent of the gastrointestinal tract, with non-specific clinical presentation and poor prognosis (Fong et al, 2000). When the tumor is confined to the gallbladder wall, the 5-year survival rate ranges from 10% to 30% (Yee et al, 2002). When the tumor invades the gallbladder serosa, local lymph nodes, or adjacent liver, the 5-year survival rate decreases to 5% (Yee et al, 2002; Czito et al, 2005). By making the retrospective analysis of the 132 cases of gallbladder cancer patients, the aim of this article is to explore the possible risk factors of the prognosis, so as to improve the survival rate of gallbladder carcinoma
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