Abstract
BackgroundThe purpose of this study is to compare the diagnostic value, imaging quality and apparent diffusion coefficient (ADC) value of reduced field-of-view diffusion-weight imaging (r-FOV DWI) and full field-of-view diffusion-weight imaging (f-FOV DWI) in patients with gallbladder carcinoma and other lesions of gallbladder.MethodsTwo hundred ninety-six patients with gallbladder diseases underwent both r-FOV DWI and f-FOV DWI on a 3.0 T MRI scanner. Two radiologists assessed subjective image quality parameters independently. The Wilcoxon signed-rank test was used to compare subjective qualitative image score. Objective quality values and the mean ADC values were analyzed by paired t-test. The correlation between pathological results and mean ADC value were estimated using Spearman rank correlation analysis.ResultsThe CNR value (10.23 ± 2.92) and image quality score (13.84 ± 1.07) of r-FOV DWI were significantly higher than those of f-FOV DWI (5.24 ± 1.29 P<0.001; 10.41 ± 1.11 P<0.001). There was no significant difference between mean ADC values of the two DWI sequences for all three groups (Group 1, chronic cholecystitis; Group 2, benign lesions of gallbladder; Group 3, gallbladder carcinoma. P = 0.239, 0.974 and 0.226 respectively). For both DWI sequences, the mean ADC values were the highest in the group of cholecystitis and the lowest in the group of gallbladder carcinoma (2.49 ± 0.14 vs 1.49 ± 0.12; 2.50 ± 0.14 vs 1.50 ± 0.13, for f-FOV and r-FOV respectively), the differences among groups were statistically significant (P<0.01). The mean ADC values for both DWI sequences were negatively correlated with the group number, which increased with the malignant tendency of lesions (r = − 0.892, P<0.01; r = − 0.913, P<0.01 for f-FOV and r-FOV respectively).ConclusionReduced Field-of-view Diffusion-weighted MRI is a good tool to diagnosis the gallbladder carcinoma, with better image quality and without affecting ADC values.
Highlights
The purpose of this study is to compare the diagnostic value, imaging quality and apparent diffusion coefficient (ADC) value of reduced field-of-view diffusion-weight imaging (r-FOV diffusion weighted imaging (DWI)) and full field-of-view diffusion-weight imaging (f-FOV DWI) in patients with gallbladder carcinoma and other lesions of gallbladder
Pathological Results Of all 61 patients, the pathological results revealed 22 cases (36.06%) of gallbladder carcinoma, 7 cases (11.48%) of gallbladder adenoma, 7 cases (11.48%) of gallbladder adenomyomatosis, 3 cases (4.92%) of gallbladder polyps and 22 cases (36.06%) of cholecystitis. These cases were divided into 3 groups according to the malignant tendency of the lesion (Group 1, chronic cholecystitis; Group 2, benign lesions of gallbladder including gallbladder adenomyomatosis, gallbladder adenoma and gallbladder polyps; Group 3, gallbladder carcinoma), the larger the group number was, the more likely the lesion tends to be malignant
Interobserver Variability of Image Quality Objective image quality values (SNR, CNR) of both DWI methods had good to excellent agreement
Summary
The purpose of this study is to compare the diagnostic value, imaging quality and apparent diffusion coefficient (ADC) value of reduced field-of-view diffusion-weight imaging (r-FOV DWI) and full field-of-view diffusion-weight imaging (f-FOV DWI) in patients with gallbladder carcinoma and other lesions of gallbladder. Primary gallbladder carcinoma is a common malignant tumor of the biliary system with high lethal malignancy and poor prognosis. Detection and treatment of gallbladder cancer can improve the prognosis. Some benign lesions, such as gallbladder adenoma and gallbladder polyps, have risk of developing malignancy and require early detection and treatment [1]. A reported 5-year survival rate of advanced gallbladder cancer is merely 3% [2]. Early detection and differentiation benign lesions from malignant lesions for gallbladder are of great significance for clinical treatment
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