Gall stones size, number, biochemical analysis and lipidogram- an association with gall bladder cancer: a study of 200 cases

Usha Bandlish,Mohinder Bal,Sunder Goyal,Parul Goyal,Shveta Narang

doi:10.14319/ijcto.0203.10

Abstract

Purpose : Objective of the study was to find out if there is any relation of number, size and type of gall stones and patient’s lipid profile with the occurrence of gall bladder carcinoma (GBC) as presence of gall stones is considered to be the most important risk factor for gall bladder cancer. Methods : 200 specimens of post-cholecystectomy gallbladder were studied. The number, size and type of stones and lipid profile were compared in all these cases. Gross as well as histopathological examination of gall bladders specimens was done. Results : 185 (92.5%) gall bladders were associated with gall stones. On histopathological examination, malignancy was found in 6 cases (3%) only and rest 194 cases (97%) revealed inflammatory/ non-neoplastic pathology. A statistically significant difference was observed in the number of stones in gall bladders with malignancy than those with benign lesions (P 0.005). Conclusion : Thus we concluded that as the number, size and cholesterol gall stone increase the risk of gall bladder cancer also increases without any relation with lipid profile. Cite this article as: Narang S, Goyal P, Bal MS, Bandlish U, Goyal S. Gall stones size, number, biochemical analysis and lipidogram- an association with gall bladder cancer: a study of 200 cases. Int J Cancer Ther Oncol 2014; 2 (3):020310. DOI: 10.14319/ijcto.0203.10

Highlights

Gallbladder cancer (GBC) was first described by Maximillian Stoll in 1777 and even after 200 years, it is still considered to be an extremely malignant disease with a poor prognosis.[1, 2] Though this type of cancer is uncommon in US and Europe, it is common in Chile, Peru, Japan and Korea.[3]
Epidemiology studies demonstrate a close association between gallbladder carcinoma (GBC) and gall stones.[5,6,7,8,9,10,11]
We examined the effect of serum lipids and lipoproteins (HDL, Low density lipoprotein (LDL)) on the risk of gallbladder carcinoma (GBC)

Summary

Introduction

Gallbladder cancer (GBC) was first described by Maximillian Stoll in 1777 and even after 200 years, it is still considered to be an extremely malignant disease with a poor prognosis.[1, 2] Though this type of cancer is uncommon in US and Europe, it is common in Chile, Peru, Japan and Korea.[3]. Epidemiology studies demonstrate a close association between gallbladder carcinoma (GBC) and gall stones.[5,6,7,8,9,10,11] Alt-

Methods

Results

Conclusion