Abstract
Purpose: Cartilage consists of numerous glycoproteins and proteoglycans, which are of significance for its functionality. Lectins are proteins that bind to specific carbohydrate structures and can thus recognize particular glycoconjugates to induce diverse physiological or pathological processes. In osteoarthritis (OA), we previously determined the altered glycophenotype of cartilage and chondrocytes, and observed the accumulation of Galectin-1 (Gal-1), Gal-3, Gal-8 and Gal-4 in severely degenerated cartilage.
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