Abstract
Background and aimsThe pathogenesis of oral-intestinal allergy syndrome (OIAS) has not been well understood. Published data indicate that galectin (Gal) 1 has immune regulatory functions. This study tests a hypothesis that Gal1 inhibits oral-intestinal allergy syndrome.MethodsMice were sensitized to peanut extracts (PE) via the buccal mucosa with or without using Gal1 together.ResultsUpon re-exposure to specific antigen, the OIAS mice showed the systemic allergic response, the oral allergic reactions, and intestinal allergic inflammation, including increases in serum histamine, drop of the core temperature, higher levels of PE-specific IgE and interleukin (IL)-4. Increases in mast cell and eosinophil in the oral mucosa and intestinal mucosa were also observed. The OIAS was inhibited by co-administration with Gal1 via a mechanism of suppressing micro RNA (miR)-98 and reversing the expression of IL-10 in CD14+ cells in the intestine.ConclusionsThe OIAS can be induced by applying specific antigens to the oral mucosa, which can be inhibited by co-administration with Gal1.
Highlights
The oral allergy syndrome is a common phenomenon
The oral-intestinal allergy syndrome (OIAS) was inhibited by co-administration with Gal1 via a mechanism of suppressing micro RNA-98 and reversing the expression of IL-10 in CD14+ cells in the intestine
The OIAS can be induced by applying specific antigens to the oral mucosa, which can be inhibited by co-administration with Gal1
Summary
The oral allergy syndrome is a common phenomenon. It belongs to the contact allergic response that occurs upon contacting specific antigens. Oral allergy syndrome is considered a form of food allergy [2]. Oral allergic responses occur together with throat allergy and called the oral allergy syndrome [3]. Some patients with oral allergy are allergic to pollen and have hay fever, implicating some antigens in foods and fruits is structurally similar to pollen [4]. One of the clinical features of oral allergy syndrome is the local mucosal edema. The pathogenesis of oral-intestinal allergy syndrome (OIAS) has not been well understood. This study tests a hypothesis that Gal inhibits oral-intestinal allergy syndrome
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