Abstract
The expression of the mRNA encoding galanin message-associated peptide (GMAP) in human keratinocytes is upregulated by lipopolysaccharides and exposure to Candida albicans. GMAP has growth-inhibiting activity against C. albicans and inhibits the budded-to-hyphal-form transition, establishing GMAP as a possible new component of the innate immune system.
Highlights
The expression of the mRNA encoding galanin message-associated peptide (GMAP) in human keratinocytes is upregulated by lipopolysaccharides and exposure to Candida albicans
The commensal organism Candida albicans resides on epithelial surfaces and is the major fungal pathogen in humans [11]
PpGAL mRNA was detected in the epidermis, hair follicles, sweat glands, and around the blood vessels of human skin [7]
Summary
The expression of the mRNA encoding galanin message-associated peptide (GMAP) in human keratinocytes is upregulated by lipopolysaccharides and exposure to Candida albicans. GMAP has growth-inhibiting activity against C. albicans and inhibits the budded-to-hyphal-form transition, establishing GMAP as a possible new component of the innate immune system. The pathogenicity of C. albicans is due to its different growth forms: the highly proliferative yeast (budded) form and the hyphal form supporting invasion into the host.
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