Abstract
Three patients who had galactorrhea as the presenting feature of primary hypothyroidism are described and, in two of them, the galactorrhea was the sole clinical manifestation. High circulating levels of prolactin were documented in all cases. In two patients, specific replacement therapy with thyroxine resulted in the resolution of the galactorrhea and normalization of the high serum thyrotropin (TSH) and prolactin levels. In the third patient, the primary hypothyroidism was transient, and the galactorrhea resolved with concomitant spontaneous improvement of the thyroid function. The diagnostic and clinical relevance of galactorrhea in the context of subclinical hypothyroidism is emphasized.
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