Abstract
IntroductionA steroid-immunosuppressed rat model of invasive pulmonary aspergillosis was use to examine the usefulness of galactomannan enzyme immunoassay (GM) and quantitative real time PCR (RT-PCR) in evaluating the association between response and exposure after a high dose of prophylactic posaconazole. MethodsTwo different strains of Aspergillus fumigatus with different in vitro posaconazole susceptibility were used. ResultsSerum concentrations demonstrated similar posaconazole exposure for all treated animals. However, response to posaconazole relied on the in vitro susceptibility of the infecting strain. After prophylaxis, galactomannan index and fungal burden only decreased in those animals infected with the most susceptible strain. ConclusionThis study demonstrated that both biomarkers may be useful tools for predicting efficacy of antifungal compounds in prophylaxis.
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