Abstract
Background: Normal pressure hydrocephalus (PNH) is manifested by the triad apraxia of gait, dementia and urinary incontinence. The fear of falling and the loss of a sense of self-efficacy in body balance and mobility results in the restriction of social participation. Objective: to verify the relationship between gait speed and self-efficacy for falls in individuals with PNH. Methodology: This is an observational and cross-sectional study, carried out at the Clinical School of Physiotherapy at UNIFRAN, with CEP approval (CAAE 83164918.2.0000.5495). The convenience sample consisted of 3 individuals with PNH, with DVP, age 72.5 (± 3.6), who presented independent gait without using a walking aid device and MMSE 23.6 (± 1.2) and a history of more than 2 falls in the past year. They were assessed for the sense of self-efficacy for falls using the Falls Efficacy Scale - International (FES-I) questionnaire. The speed of normal and fast gait was calculated by the time taken to cover 10 meters. To verify the relationship between FES-I and gait speed, association and correlation tests were applied. Descriptive analysis was performed and the paired t test and the Pearson correlation test were used. Results: The FEI-S average was 31.3 ± 4.8 points. The average normal walking speed was 0.62 ± 0.24m / s and the average fast speed was 0.77 ± 0.32m / s. The participants were not able to significantly modify the gait speed (p = 0.073). There was a positive correlation between FES-I and gait speed (r = 0.68; p = 0.027). Conclusion: The low self-efficacy for falls interferes with the ability to change the gait pattern through speed. Understanding the fear of falling and walking speed can help in the mapping of cases that deserve, in addition to conventional rehabilitation, a behavioral intervention to increase the sense of self-efficacy, and thereby improve walking independence.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
Objectives: The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
The analyses showed significantly higher frequency of the genotype VV in those who had depression, compared with the allele A
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Neuroinfections are pathologies that affect the CNS, for example, we have Murcomycosis, a progressive infection caused by opportunistic fungi of the order Mucorales, with high frequency in Immunodepressed patients, Diabetes Mellitus (DM) is the main underlying pathology associated with the development of Rhinocerebral Murcomycosis, which represents 50% of the cases, with a mortality rate of 70% (Sidrim, 2012, p.168). The COVID-19 pandemic has been alarming the world since its first outbreak in December 2019 In this scenario, the presence of aggravating factors such as the elevation of the D-dimer and the reduction of the angiotensin-converting enzyme 2 (ACE2) during the clinical course of the disease, collaborated in the appearance of thromboembolic events derived from inflammatory processes and extensive intravascular coagulation, contributing to the emergence of diseases such as Hemorrhagic Stroke (ICH), leading the patient to have a worse clinical prognosis and a consecutive worsening of their health. Despite being classically associated with this etiology, the finding may be present in other diseases, especially infiltrative ones
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
