Abstract
HIV-1 Vpu plays important role in enhancing virus release and CD4 down-modulation. We investigated the effect of Vpu-Gag cross talk on envelope incorporation and assembly in different cell types including primary cells.
Highlights
HIV-1 Vpu plays important role in enhancing virus release and CD4 down-modulation
We investigated the effect of Vpu-Gag cross talk on envelope incorporation and assembly in different cell types including primary cells
We introduced Vpu start codon mutation and point substitution in p17 Gag matrix (L30E) in HIV-1 pNLAD8 through PCR
Summary
HIV-1 Vpu plays important role in enhancing virus release and CD4 down-modulation. We investigated the effect of Vpu-Gag cross talk on envelope incorporation and assembly in different cell types including primary cells. Gag-Vpu cross talk modulating HIV-1 envelope incorporation and infectivity in cell-type dependent manner From First International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2012) Chennai, India. Introduction HIV-1 Vpu plays important role in enhancing virus release and CD4 down-modulation.
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