Abstract
Gadolinium Retention in the Human Body after Administration of Magnetic Resonance Contrast Agents: Where We are Now
Highlights
The use of Gadolinium as MRI contrast agent is due to its strong ability to reduce T1 in tissues, inducing a high contrast efficiency
Research about Gd retention started with a paper published by Kanda et al, [4] in which authors reported a linear increase of dentate nucleus and globus pallidus T1 signal intensity and its correlation with the number of previous Gadolinium Based Contrast Agents (GBCA) injections
This study showed for the first time that hyperintensity in the dentate nucleus could be related to a history of brain irradiation or secondary progressive subtype of multiple sclerosis, but to the number and the total amount of GBCA administered
Summary
The use of Gadolinium as MRI contrast agent is due to its strong ability to reduce T1 in tissues, inducing a high contrast efficiency.
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