Abstract
Magnetic resonance imaging (MRI) is indispensable and powerful in modern clinical diagnosis and has some advantages such as non-invasiveness and high penetration depth. Furthermore, dual T1–T2 MR imaging has attracted crucial interest as it can decrease the risk of pseudo-positive signals in diagnosing lesions. And it's worth nothing that the dual-mode MR imaging displays a vital platform to provide relatively comprehensive diagnosis information and receive accurate results. Herein, we report a dual T1–T2 MR imaging contrast agent (CA) grounded on the iron/iron oxide core/shell nanomaterials conjugated with gadolinium chelate. The Gd-labeled Fe@Fe3O4 NPs reveal the feasibility to utilize them to serve as a dual T1–T2 MR imaging CA, and the relaxivity results in a 0.5 T MR system showed a longitudinal relaxivity value (r1) and transverse relaxivity value (r2) of 7.2 mM−1 s−1 and 109.4 mM−1 s−1, respectively. The MTT results demonstrate the Gd-labeled Fe@Fe3O4 NPs have no obvious cytotoxicity and a good compatibility. The in vitro and in vivo MRI generated a brighter effect and darkening in T1-weighted MR imaging and T2-weighted images, respectively. The results clearly indicate that Gd-labeled Fe@Fe3O4 NPs have potential as a magnetic resonance imaging contrast reagent.
Highlights
Cancer has become a predominant cause of death across the world and seriously threatens human health.[1,2] exact diagnosis of cancer becomes extremely important
The Gd-labeled Fe@Fe3O4 NPs reveal the feasibility to utilize them to serve as a dual T1–T2 MR imaging contrast agent (CA), and the relaxivity results in a 0.5 T MR system showed a longitudinal relaxivity value (r1) and transverse relaxivity value (r2) of 7.2 mMÀ1 sÀ1 and 109.4 mMÀ1 sÀ1, respectively
The results clearly indicate that Gd-labeled Fe@Fe3O4 NPs have potential as a magnetic resonance imaging contrast reagent
Summary
Cancer has become a predominant cause of death across the world and seriously threatens human health.[1,2] exact diagnosis of cancer becomes extremely important. As one of the most excellent modern clinical imaging techniques, MRI has become an extremely important part due. Long et al reported an underlying T1–T2 MRI probe of gadolinium-labelled Fe3O4 nanoparticles but did not further used especially in vivo.[28] Inspired by this, in order to get even more in-depth imaging information and expand the application of the probe, we conjugated the Gd chelates onto Fe@Fe3O4 nanoparticles to create a platform for dual modal detection. The Fe@Fe3O4, capping with oleic and oleylamine, was formed through the thermal decomposition approach. In this procedure, Fe(CO)[5] was utilized as a precursor. Our results indicated that DOTA(Gd)Fe@Fe3O4 NPs played an important role in tumor diagnosis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
