Abstract
Gadolinium is a contrast agent used routinely for magnetic resonance imaging (MRI). It is safe, well tolerated and has shown no nephrotoxicity at the recommended doses. 1 Spinosa D. Matsumoto A. Hagspiel K. Angel J.F. Hartwell G. Gadolinium-based contrast agents in angiography and interventional radiology. AJR. 1999; 173: 1403-1409 Crossref PubMed Scopus (49) Google Scholar , 2 Hammer F.D. Malaise J. Goffette P.P. Mathurin P. Gadolinium Dimeglumine an alternative contrast agent for digital substraction angiography in patients with renal failure. Transplant Proc. 2000; 32: 432-433 Abstract Full Text Full Text PDF PubMed Scopus (22) Google Scholar , 3 Parodi J.C. Ferreira L.M. Gadolinium-based contrast an alternative contrast agent for endovascular interventions. Ann Vasc Surg. 2000; 14: 480-483 Abstract Full Text PDF PubMed Scopus (21) Google Scholar , 4 Spinosa D.J. Matsumoto A.H. Angle J.F. Hagspiel K.D. Leung D.A. Hartwell G.D. Gadolinium contrast agents their role in vascular and nonvascular diagnostic angiography and interventions. Tech Vasc Interv Radiol. 2001; 4: 45-52 Abstract Full Text PDF PubMed Scopus (10) Google Scholar , 5 Adding L.C. Bannenberg G.L. Gustafsson L.E. Basic experimental studies and clinical aspects of gadolinium salts and chelates. Cardiovasc Drug Rev. 2001; 19: 41-56 Crossref PubMed Scopus (106) Google Scholar Intra-arterial gadolinium has already been used to visualize small and medium size arteries. 6 Nussbaum E.S. Casey S.O. Sebring L.A. Use of gadolinium as an intraarterial contrast agent in digital substraction angiography of the cervical carotid arteries and intracranial circulation. Neurosurg. 2000; 92: 881-883 Crossref Scopus (25) Google Scholar We recently reported the use of gadolinium to perform selective intracranial angiography to visualize an aneurysm before surgical clipping. 7 Slaba S.G. El-Hajj L.F. Abboud G.A. Jebara V.A. Selective angiography of cerebral aneurysm using Gadodiamide in polycystic kidney disease with renal insufficiency. AJR. 2000; 175: 1467-1468 Crossref PubMed Scopus (14) Google Scholar The perfect tolerance of this agent encouraged us to perform the first coronary angiography that used gadolinium. 8 Sarkis A. Badaoui G. Slaba S. Moussalli A. Jebara V. Gadolinium-based coronarography in a patient with renal failure first clinical report. Cathet Cardiovasc Intervent. 2001; 54: 68-69 Crossref PubMed Scopus (19) Google Scholar The aim of this prospective report is to establish the efficacy and safety of gadolinium enhanced with low-dose nonionic contrast agents for coronary angiography in patients with impaired renal function.
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