Abstract
A novel folic acid-imprinted quartz crystal microbalance (QCM) nanosensor in order to detect folic acid depending on the fabrication of folic acid-imprinted polymer film on a QCM electrode was developed with methacrylamidoantipyrine–gadolinium (III) [MAAP–Gd(III)] used as a monomer for metal coordination–chelation interaction to obtain a more selective molecularly imprinted polymers (MIPs). The developed folic acid-imprinted nanosensor on the MIP/QCM detection system showed outstanding properties such as a stronger affinity of 3.07 × 107 M−1, a short response time of 10 min, wider linear range of 0–100 µM, a selectivity of k = 8.25 and lower detection limit of 0.0080 µM. After characterizing its all features, the newly designed folic acid-imprinted QCM nanosensor was utilized to detect folic acid level in commercial follow-on baby milk in order to determine its use in real samples.
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