Abstract
Mimusops elengi L. , Averrhoa carambola L. and Curcuma xanthorrihiza Roxb singly were reported to have hypothensif effect. Mechanism underlying decrease of blood pressure was suggested through modification of cardiac activity. The Effect of Mimusops elengi L., combined with Averrhoa carambola L. and Curcuma xanthorrihiza Roxb extract on cardiac activity were studied using ECG on 12 male cats that were grouped to be a control group administered aquadestilata, and treatment group administered extract of 21 mg and 82 mg/2 kg bw orally respectively. The extracts were given 3 h prior to ECG. The results showed a decrease in P wave, QRS complex and the speed of the heart rate after administration of combination of extract . However QT and PR intervals were increased. This showed that the extract can weaken a contraction of the Atria and ventricles, prolonging the onset of the occurrence of atrial contraction towards ventricular contraction, extending the onset of contraction and relaxation of the ventricles and cause a decrease in heart rate. Based the cardiogram, It was concluded that their combination is valuable for treatment of aritmia.
Highlights
Penyakit kardiovaskuler merupakan salah satu penyakit yang menjadi permasalahan cukup serius dewasa ini
The results showed a decrease in P wave, QRS complex and the speed of the heart rate after administration of combination of extract
Folia Medica Indonesiana Vol 48 No 4: 198-202 World Health Organization, Global Health Estimates 2014 Summary Tables: Deaths by Cause, Age and Sex, by WHO Region, 2000–2012, http://www.who.int/ healthinfo/global burden disease/en/2014 [Internet] Accessed: Monday 23rd March 2015, Available from
Summary
Penyakit kardiovaskuler merupakan salah satu penyakit yang menjadi permasalahan cukup serius dewasa ini. Hal ini sejalan dengan meningkatnya prevalensi penyakit kardiovaskuler akibat adanya perubahan gaya hidup, Daun tanjung (Mimusops elengi L.), dan belimbing manis (Averrhoa carambola L.) serta Rimpang Temulawak (Curcuma xanthorrihiza) berpotensi sebagai obat untuk mengendalikan penyakit jantung. Hasil analisis fitokimia baik daun tanjung, belimbing manis maupun rimpang temulawak, mengandung flavonoid, fenol, saponin dan tanin. Senyawa flavonoid dan fenol dilaporkan oleh beberapa peneliti dapat menurunkan tekanan darah melalui mekanisme hambatan terhadap sistem saraf simpatis (simpatolitik) atau meningkatkan kerja parasimpatik (parasimpatomimetik), yaitu relaksasi otot atau melalui syaraf pusat. September 2019 Vol 20 No 3 : 409-417 ekstrak daun tanjung (Mimusops elengi L.), daun belimbing manis (Averrhoa carambola L.) dan rimpang temulawak (Curcuma xanthorrihiza Roxb.) terhadap gambaran EKG jantung kucing sebagai model. Selain itu menurut Buchanan (1999) dan Payne et al (2015), 10% dari populasi kucing di seluruh dunia menderita penyakit jantung
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