Abstract
Tumor metastasis is the main reason for the poor prognosis of lung cancer patients. The GABAA receptor subunit GABRA3 is reportedly upregulated in lung cancer. Herein, we show that high GABRA3 protein expression in lung adenocarcinoma correlated positively with disease stage, lymphatic metastasis status and poor patient survival. In addition, GABRA3 induced MMP-2 and MMP-9 expression through activation of the JNK/AP-1 signaling pathway, which enhanced lymphatic metastasis by lung adenocarcinoma both in vitro and in vivo. These results indicate that GABRA3 promotes lymph node metastasis and may thus be an effective therapeutic target for anticancer treatment.
Highlights
Transcript levels were normalized by GAPDH expression. (D) MMP-2 and MMP-9 protein levels in the supernatants of indicated cell cultures were assessed using ELISAs
No patients HR P-value Hazard Ration HR P-value Hazard Ration
Transcript levels were normalized to GAPDH expression
Summary
GABRA3 promotes lymphatic metastasis in lung adenocarcinoma by mediating upregulation of matrix metalloproteinases www.impactjournals.com/oncotarget
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