Abstract
Drugs affecting the GABAergic transmission were injected into the medial preoptic anterior hypothalamic area (MPOA) and the masculline sexual behavior analyzed. Antagonizing GABAergic neurotransmission by (+) bicuculline methiodide (30 ng/cannula), picrotoxin (50 ng/cannula), or 3-mercaptopropionic acid (10 or 20 μg/cannula) resulted in a drastic shortening of the postejaculatory intervals and a shortening of the ejaculation latency. Injection of compounds causing an increase in GABAergic activity, muscimol (25 ng/cannula) or ethanolamine-O-sulphate (80 μg/cannula) depressed masculine sexual behavior. Systemic treatment or injection into the nucleus caudatus putamen of compounds affecting the GABAergic transmission did not cause any alteration in the mating pattern. It is suggested that the GABAergic neurotransmission is involved in inhibitory processes underlying the masculine sexual behavior.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.