Abstract
Acutely dissociated and cultured chick and rat dorsal root ganglion (DGR) neurons were studied by means of whole-cell patch-clamp technique. The high voltage-activated calcium current in DRG neurons is a result of mixture of N-type (ω-conotoxin-sensitive), P-type (ω-aga-IVA-sensitive), and L-type (dihydropyridine-sensitive) calcium currents. The modulation of these calcium channel currents in DRG neurons involves the GTP binding proteins and GABAB receptors. This kind of modulation occurs at presynaptic terminalsin vivo due to synaptically released GABA resulting in a primary afferent inhibition.
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