Abstract
Studies of the effects of thyroid hormones on the uptake of neurotransmitters by homogenates of rat cerebral cortex have revealed a significant competitive inhibition of neuronal uptake of [ 3H]GABA by thyroid hormones (T 1 > T 4 > rT 4). The IC 50 for inhibition of GABA uptake by T 3 was estimated at 4 μM and that of T 4 at 11 μm. GABA uptake in homogenates of cerebral cortex from hypothyroid rats was significantly enhanced over that of controls; however, uptake in tissues from hyperthyroid rats was not significantly diminished.
Highlights
THE INFLUENCE of hormones on behavior has long been recognized
We have broadened our investigation to include the effects of thyroid hormones on the synaptic components of other neurotransmitter systems, including the gmma-aminobutyric acid (GABA) system
We found that 70 ± 20Jo of the uptake of l3HIGABA in the homogenates could be blocked by 10-M diaminobutyric acid (DABA), an inhibitor of neuronal GABA uptake (Schon & Kelly, 1974), but the same concentration of beta-alanine (Schon & Kelly, 1974) inhibited only 9 ± I OJo of I3H !GABA uptake
Summary
Psychoneuroendoamology, Vol 12, No I, pp. 53 - 59. 1987 Printed in Great Britain. 0306-453018H3.00 + 0.00 Pergamon Journals Ltd. 0306-453018H3.00 + 0.00 Pergamon Journals Ltd. GEORGE A. SUl\11\IARY Studies of the effects of thyroid hormones on 1he up1akc of neuro1ransmitters by homogenates of rat cerebral cortex have revealed a significant competitive inhibition of neuronal uptake of IiHIGABA by thyroid hormones (T," T," rT,). The IC,, for inhibition of GABA uptake by T, was estimated at 4 μMand that of T, at 11 μm. GABA uptake in homogenates of cerebral cortex from hypothyroid rats was significantly enhanced mer that of controls: uptake in tissues from hyperthyroid rats was not significantly diminished
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
