Abstract
The effect of γ-aminobutyric acid (GABA) mimetics on extracellular concentrations of 5-hydroxyindoleacetic acid (5-HIAA) (as measured by differential pulse voltammetry with carbon fiber electrodes) in the dorsal raphe´has been investigated in the rat. Systemic administration of dipropylacetamide decreased extracellular 5-HIAA to a similar extent, and within a comparable time course, in the dorsal raphe´and striatum. Similar results were obtained after intradorsal raphe´infusion of muscimol (100 ng). In contrast, local infusion of tetrodotoxin into the dorsal raphe´failed to alter serotonin metabolism in this area. It is concluded that GABA depresses serotonin metabolism not only in nerve endings, but also in dendrites (and/or cell bodies) of serotonergic neurons.
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