Abstract
Larvae of the marine gastropod mollusc, Haliotis rufescens, display an absolute requirement for GABA (or specific GABA homologs and analogs) for induction of genetically programmed behavioral and developmental metamorphosis to the juvenile form. Systematic investigation of the Stereochemical specificity of this requirement, its sensitivity to inhibition by non-inducing GABA analogs, and the effects of neuropharmacological probes of GABA function reveal the involvement of GABA receptor and/or early processing sites similar to those in mammalian brain. Convenient, quantitative analyses of the GABA-dependent behavioral and developmental transition in these experimentally tractable larvae can provide fundamental information on the mechanisms of induction and control of developmental processes by this major neurotransmitter, and the sensitivities of these processes to GABA agonists and antagonists.
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