Abstract
The effect of GABA on potassium-evoked tritium release from two sizes of ribbon of rat striatum previously loaded with [ 3H]dopamine was studied. GABA had no effect on the release of tritium from 100 × 100 μm ribbons but produced a dose-related enhancement of potassium-evoked tritium release from 250 × 250 μm ribbons. The enhancement was unaffected by the presence of bicuculline or picrotoxin but was antagonised by tetrodotoxin. The effect of GABA was not mimicked by the GABA agonists muscimol or baclofen. The possible involvement of an interneurone is discussed. From antagonist studies the neurotransmitter released by the postulated interneurone did not appear to be acetylcholine, 5-hydroxytryptamine, glycine, glutamate of enkephalin.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
