Abstract
Intracellular recordings of cultured mouse spinal neurons were used to examine the effects of γ-aminobutyric acid (GABA) and the GABA analog muscimol on neuronal excitability. Muscimol was about twice as effective as GABA in increasing membrane conductance to C1-ions. Fluctuation analysis of membrane current responses showed that muscimol activated ion channels with the same conductance as GABA but with about twice the average duration. The results provide an economical explanation for the greater potency of muscimol in depressing excitability.
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