Abstract
Currents activated by gamma-aminobutyric acid (GABA) were recorded in single Purkinje cells isolated from the rat cerebellum and trigeminal ganglia. All neurons tested were GABA-sensitive. Reversal potential of GABA-activated current matched equilibrium potential for chloride ions as determined by Nernst's equation. The dose-response curve was described by Langmuir's isotherm with a dissociation constant (Kd) of 1.4·10−4 M. Nembutal did not just increase the amplitude of GABA-activated current but also activated matching ionic conductance in the absence of GABA. Ionic currents activated by GABA were reversibly blocked by bicuculline methiodide and isocoryne.
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