Abstract
Immunoreactivity of GABA A receptor subunits and the receptor anchoring protein gephyrin was investigated in the human globus pallidus using antibodies raised against the α 1 and γ 2 subunits of the GABA A receptor complex and gephyrin. The results revealed increased GABA A receptor subunit immunoreactivity and unchanged levels of gephyrin immunoreactivity in Huntington's diseased (HD) globus pallidus (GP). The results demonstrate that gephyrin immunoreactivity did not change in unison with GABA A receptor changes in HD, suggesting that the receptor anchoring protein gephyrin is unaltered and maintains a stable lattice structure in the face of GABA A receptor changes in HD.
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