Abstract
Autoradiography revealed picrotoxin-sensitive [ 35S]TBPS([ 35S]t-butylbicyclophosphorothionate) binding sites in the cerebellar granule cell layer only in the presence of GABA A receptor antagonists. However, under the same conditions, the binding was decreased in other brain regions, including the cerebellar molecular cell layer. Thus, the convulsant binding sites at GABA A receptors in the granule cell layer are highly sensitive to down-regulation by GABA, which may be due to a unique combination of receptor subunits.
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