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Abstract
The activity of the enzymes GABA—2-oxoglutarate transaminase (GABA-T) and glutamate decarboxylase (GAD), the endogenous GABA content and the half-life of GABA have been estimated in whole rat brain, cerebellum, pons/medulla, midbrain, cerebral cortex/hippocampus, striatum and hypothalamus. The efflux of 3H-GABA in all brain areas consists of at least two components, a fast phase having a half-life of between 0.5 and 1 hr and a slower phase with a half-life exceeding 1 hr. In addition, significant differences in the calculated rates of GABA turnover among brain regions were found. Endogenous GABA and also the faster turnover phase are proportional to GAD activity but are not dependent on concomitant GABA-T activity. The possible significance of these results are discussed in relation to the postulated role of GABA as a neurotransmitter in the CNS.
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