Abstract
Background Volume-targeted ventilation is used widely but different modes have not been compared using clinically relevant outcomes. Aims To compare volume-controlled ventilation (VCV) with volume guarantee (VG) using short-term clinical outcomes in preterm infants with respiratory distress syndrome (RDS). Methods This RCT recruited in a tertiary UK neonatal unit (ISRCTN no. 04448562). Infants born at Results 113 infants were enrolled. One ineligible infant was withdrawn. Mean GA and median birth weight in the VCV and VG groups were 27w and 1080g, and 27w and 1020g respectively. Respiratory status at trial entry was comparable between groups. Overall, and within the first 48 hours, there were no significant differences between groups in the primary outcome or in duration of ventilation. There were no differences between groups in important secondary outcome measures. CI, confidence interval Conclusion In preterm infants with RDS there was no difference between VCV and VG in time to ‘success’ criteria or in duration of ventilation. Secondary outcome measures were similar irrespective of trial mode.
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