Abstract
Metabolic stress due to nutrient excess and lipid accumulation is at the root of many age-associated disorders and the identification of therapeutic targets that mimic the beneficial effects of calorie restriction has clinical importance. Here, using C. elegans as a model, we studied the roles of a recently discovered enzyme at the heart of metabolism in mammalian cells, glycerol 3-phosphate phosphatase (G3PP) (gene name Pgp) that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol. Gro3P is a key metabolite that regulates flux of various metabolic pathways and particularly the glycerolipid/fatty acid (GL/FA) cycle associated with obesity, type 2 diabetes, and cardiometabolic disorders.
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