G256 Validation of transcutaneous bilirubinometry as a method to monitor newborn jaundice in a low income country

Abstract

Background and aims Kernicterus is a significant problem in low income countries (LICs) and measurement of total serum bilirubin (TSB) is often restricted by cost or lack of laboratory facilities. Near patient testing through the use of transcutaneous bilirubinometry (TcB) may be of benefit in LICs. Therefore, the aim of this study was to determine agreement between (TcB) and TSB in a LIC (Haiti). Methods With approval the Ministry of Health, we conducted a single centre prospective study (February-May 2017) in a NGO funded neonatal unit in northern Haiti. Babies with clinically detected jaundice, Results Paired TcB/TSB measurements were obtained from 35 infants. 19 (54.3%) were male; 23 (65.7%) were ≥35 weeks, 12 (34.3%) 200 µmol/L), TcB tended to underestimate bilirubin in comparison to TSB and the magnitude of the difference increased. The mean difference between TcB and TSB was increased in babies 35 weeks 8.4µmol/L (95% CI −18.5, 35.3). Conclusion Our data indicate good agreement between TcB and TSB levels in Haitian newborns receiving phototherapy. Implementing TcB measurement for the management of newborn jaundice is both feasible and convenient as an alternative to laboratory TSB measurements in preterm and term babies during phototherapy in a LIC setting.