Abstract
A novel self-regulating drug release system was fabricated and tested. The system consists of two units: decompression unit so-called "organic engine" and drug release unit. Glucose oxidase (GOD) immobilized membrane was utilized to "organic engine" for converting chemical energy of the glucose to mechanical work as a pressure changes of consumed oxygen in the GOD reaction. Pressure changes caused by GOD reaction of the decompression unit was in good correlation to the glucose concentrations. Afterward, the drug release unit which utilizes the energy of the "Organic engine" as a power source was fabricated and evaluated by recording its release actions. The system was then fabricated by combining the both units. As an evaluation result of the system, the feasibility of feedback control of glucose concentration by the chemo-mechanical drug release system was shown.
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